3,306
个编辑
更改
无编辑摘要
[[阿托伐他汀]]片.立普妥.20mg*7片.[[辉瑞制药有限公司]]
:【别名】[[立普妥]] , [[阿托伐他汀钙]]
【外文名】Lipitor , Atorvastatin Calcium
===药理毒理===
本品为HMG-CoA[[还原酶]]选择性[[抑制剂]]，通过抑制HMG-CoA还原酶和[[胆固醇]]在[[肝脏]]的[[生物合成]]而降低[[血浆]]胆固醇和[[脂蛋白]]水平，并能通过增加[[肝细胞]]表面[[低密度脂蛋白]]（LDL）[[受体]]数目而增加LDL的摄取和[[分解代谢]]。本品也能减少LDL的生成和其颗粒数。本品还能降低某些[[纯合子]]型[[家族性高胆固醇血症]]（FH）的[[低密度脂蛋白胆固醇]]（LDL-C）水平，而一类型的人群对其他类型的降脂药物治疗很少有应答。
本品能降低纯合子和[[杂合子]]家族性高胆固醇血症、非家族性高胆固醇血症以及混合性[[脂类]][[代谢障碍]]患者的血浆[[总胆固醇]]（TC）、LDL-C和[[载脂蛋白]]B（ApoB），还能降低[[极低密度脂蛋白]]胆固醇（VLDL-C）和三酰甘油（TG）的水平，并能不同程度地提高血浆[[高密度脂蛋白胆固醇]]（HDL-C）和载脂蛋白A1（ApoA1）的水平。
po，可在任何时间[[单剂量]]服用，进食或非进食时均可。起始剂量为10mg,qd，剂量范围为10～80mg.d-1。根据治疗目标和治疗反应采取个体化治疗方案。对[[肾功能不全]]患者，不必调整剂量。
===注意事项===
活动性[[肝病]]或原因不明的[[转氨酶]]持续升高患者及对本品的任何成分过敏者、孕妇和[[哺乳期]]妇女禁用。
①使用本品治疗前、治疗6周及12周或增加药物剂量后进行[[肝功能]]检测，并在以后定期测定肝功能。②治疗过程中出现弥漫性[[肌痛]]、[[肌肉]]触痛或[[无力]]，特别是伴有[[全身不适]]或[[发热]]时，或/和肌酸磷酸激酶（CPK）水平明显升高，应考虑肌病的可能性。如为肌病，应停止本品的治疗。③使用本品前，应通过适当饮食、运动和减轻[[肥胖]]的体重等方法控制高胆固醇血症，并治疗其他原发[[疾病]]。④本品过量无特殊治疗。一旦发生过量，应予以对症及相应
7的[[支持疗法]]，[[血液]]透极不能显著增加其清除。⑤开始治疗和/或增加剂量后2～4周应监测[[血脂]]水平，并据此对剂量进行相应的调整。⑥对纯合子高胆固醇血症患者，除非无法进行其他治疗，本品应作为其他降脂治疗措施（LDL血浆分离置换）基础上进行的治疗手段。
【规格】片剂：10mg，20mg,40mg。
2.Before taking atorvastatin, tell your doctor if you
*drink alcoholic beverages, *have a chronic muscular disease, *require major surgery, or *have a blood disorder.
3.You may not be able to take atorvastatin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
===不良反应===
1.If you experience any of the following serious side effects, stop taking atorvastatin and seek emergency medical attention or call your doctor immediately:
*an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); *muscle aches, pain, or weakness; *"flu-like" symptoms; *decreased urine or rust-colored urine; *blurred vision; or *yellowing of your skin or eyes.
2.Other, less serious side effects may be more likely to occur. Continue to take atorvastatin and talk to your doctor if you experience
*headache; *upset stomach or flatulence; or *a rash.
3.Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
===相互作用===
1.Do not take atorvastatin without first talking to your doctor if you are taking any of the following medicines:
*cyclosporine (Sandimmune, Neoral); *gemfibrozil (Lopid); *niacin (Nicolar, Nicobid, Nicotinex, others); *clarithromycin (Biaxin); *erythromycin (E-Mycin, E.E.S., Ery-Tab, Ilotycin, Eryc, PCE, Ilosone, others); or *fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral).
2.The medications listed above interact with atorvastatin and may cause damage your muscles.
3.Before taking atorvastatin, tell your doctor if you are taking any of the following medicines:
*other cholesterol-lowering drugs such as cholestyramine (Questran) or colestipol (Colestid); or *digoxin (Lanoxin, Lanoxicaps).
4.You may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
[[分类:药品]][[分类:降血脂药]]
