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钠钾泵

删除1,383字节, 2017年3月24日 (五) 11:03
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=== 讯息转换子 ===
在过去这些年中,许多实验室证明了这些[[膜蛋白]]除了可以做传统的离子运输外,亦可借由调控蛋白质上[[酪胺酸]]的[[磷酸化]]来结合细胞间的哇吧因(ouabain)传递讯息进入细胞内。借由哇吧因来触发蛋白质磷酸化产生的下游讯息包括[[有丝分裂]]活化[[蛋白质激酶]](mitogen-activated protein kinase, MAPK)讯息的梯瀑效应(cascade)的活化、[[粒线体]]活性氧(reactive oxygen species, ROS)的产生、C型[[磷脂酶]](phospholipase C, PLC)及[[肌醇三磷酸]][[受体]](inositol triphosphate receptor, IP<sub>3</sub>R)的活化。[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15975899 Na/K-ATPase Tethers Phospholipase C and IP3 Receptor into a Calcium-regulatory Complex] by Zhaokan Yuan, Ting Cai, Jiang Tian, Alexander V. Ivanov, David R. Giovannucci, and Zijian Xie in Molecular Biology of the Cell (2005) volume 16, pages 4034-4045. 蛋白质[[交互作用]]对钠钾帮浦媒介的讯息传递是很重要的,如:钠钾帮浦与无接收子酪胺酸[[磷酸酶]](Src,一种没有受体得酪胺酸[[激酶]])结合形成接收子[[复合物]](receptor complex)。[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16267270 Binding of Src to Na+/K+-ATPase Forms a Functional Signaling Complex] by Jiang Tian, Ting Cai, Zhaokan Yuan, Haojie Wang, Lijun Liu, Michael Haas, Elena Maksimova,‡ Xin-Yun Huang and Zi-Jian Xie in Molecular Biology of the Cell (2005) volume 17, pages 317-326.钠钾帮浦亦会与complex)。钠钾帮浦亦会与[[锚蛋白]](ankyrin)、肌醇三磷酸受体(IP<sub>3</sub>R)、肌醇三磷酸激酶(PI<sub>3</sub>K)、C型磷脂酶γ(PLC-γ)及切丝[[蛋白]](cofilin)结合。[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1221581 Interaction of the alpha subunit of Na,K-ATPase with cofilin] by K. Lee, J. Jung, M. Kim and G. Guidotti in [[Biochemical Journal|The Biochemical Journal]] (2001) volume 353, pages 377–385.
== 机制 ==
=== 内生(Endogenous) ===
钠钾泵被认为可由cAMP来调降。[http://ajpcell.physiology.org/cgi/content/full/279/5/C1516 Regulation of Na+-K+-ATPase by cAMP-dependent protein kinase anchored on membrane via its anchoring protein] Kinji Kurihara, Nobuo Nakanishi, and Takao Ueha. Departments of 1 Oral Physiology and 2 Biochemistry, School of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan若物质造成cAMP浓度上升,则钠钾泵浓度下降;反之,若cAMP浓度下降,则纳钾泵浓度上升。钠钾泵被认为可由cAMP来调降。若物质造成cAMP浓度上升,则钠钾泵浓度下降;反之,若cAMP浓度下降,则纳钾泵浓度上升。
=== 外生(Exopenous) ===
== 发现 ==
丹麦科学家延斯·克里斯蒂安·斯科(Jens Christian Skou)在1957年发现钠钾帮浦,并在1997年获得诺贝尔[[化学]]奖。"for the first discovery of an ion-transporting enzyme, Na+, K+ -ATPase." [http://nobelprize.org/chemistry/laureates/1997/index.html Chemistry 1997<!-- Bot generated title -->]
== [[基因]] ==
* Beta︰[[ATP1B1]], , [[ATP1B3]],
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