黄体生成素β亚基

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黄体生成素β亚基( 或 lutropin subunit beta )是一种由人类基因LHB 编码的蛋白质

基因

该基因位于19号染色体q13.3,编码黄体生成素的β亚基

功能

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit (this protein) which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

临床意义

Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.

延伸阅读


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