EF-G

EF-G为延伸因子G的缩写，是原核延伸因子中的。

功能

The factor EF-G catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation. Homologous to EF-Tu + tRNA, EF-G also binds to the ribosome in its GTP-bound state. When it associates with the A site, EF-G causes the tRNA previously occupying that site to occupy an intermediate A/P position (bound to the A site of the small ribosomal subunit and to the P site of the large subunit), and the tRNA in the P site is shifted to a P/E hybrid state. EF-G hydrolysis of GTP causes a conformation change that forces the A/P tRNA to fully occupy the P site, the P/E tRNA to fully occupy the E site (and exit the ribosome complex), and the mRNA to shift three nucleotides down relative to the ribosome due to its association with these tRNA molecules. The GDP-bound EF-G molecule then dissociates from the complex, leaving another free A-site where the elongation cycle can start again.

除了在翻译中的作用外，EF-G还与一起以GTP依赖方式促进核糖体再循环。

进化

EF-G有一个复杂的进化史，现代细菌基因组中存在的大量该延伸因子的旁系同源基因暗示了不同的EF-G变体可能在进化过程中发生了。

临床意义

EF-G可被抑制，但有细菌也出现了耐药性。

外部链接

这是一篇与方剂相关的条目。推荐您访问中医智库，查看权威EF-G信息。

这是一篇与医籍相关的条目。推荐您访问中医智库，阅读《EF-G》经典原文。