普瑞巴林
产品名称: 普瑞巴林
药理药效：普瑞巴林是一种新型γ-氨基丁酸(GABA)受体激动剂,能阻断电压依赖性钙通道,减少神经递质的释放,临床主要用于治疗外周神经痛以及辅助性治疗局限性部分癫痫发作。
别名: C1-1008
美国化学文摘登录号: ［ 148553-50-8 ］
分子式: C8H17NO2
分子量: 159.23
物化性质： 白色结晶性粉末
熔点 (oC) 184 - 186
Monograph Number: 7813
Title: Pregabalin
CAS Registry Number: 148553-50-8
CAS Name: (3S)-3-(Aminomethyl)-5-methylhexanoic acid
Additional Names: (S)-(+)-4-amino-3-(2-methylpropyl)butanoic acid; (S)-(+)-3-isobutyl-g-aminobutyric acid
Manufacturers' Codes: CI-1008; PD-144723
Molecular Formula: C8H17NO2
Molecular Weight: 159.23.
Percent Composition: C 60.34%, H 10.76%, N 8.80%, O 20.10%
Literature References: GABA analog. Prepn of racemate: R. Andruszkiewicz, R. B. Silverman, Synthesis 1989, 953. Enantioselective synthesis: P. Yuen et al., Bioorg. Med. Chem. Lett. 4, 823 (1994). Manufacturing process: M. S. Hoekstra et al., Org. Process Res. Dev. 1, 26 (1997). HPLC determn in biological fluids: B. L. Windsor, L. L. Radulovic, J. Chromatog. B 674, 143 (1995). Anticonvulsive activity: C. P. Taylor et al., Epilepsy Res. 14, 11 (1993). Activity in models of neuropathic pain: M. J. Field et al., Pain 80, 391 (1999).
Properties: White crystalline solid, mp 186-188? ［a］D23 +10.52?(c = 1.06 in water).
Melting point: mp 186-188°
Optical Rotation: ［a］D23 +10.52?(c = 1.06 in water)
Therap-Cat: Anticonvulsant.
