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活性位点

添加1,263字节, 2017年2月15日 (三) 14:00
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异位结合位顾名思义和活性位点是不同的位置在酵素上,异位修饰通常发生在超过一个次单元的[[蛋白质]],也常常参与[[代谢反应]]。
==参见参考文献==
* [[别构调节]] (Allosteric regulation)
* [[酶促反应]]
* [[酶抑制剂]]
==参考来源==*[#http://zhen.wikipedia.org/wiki/%E6%B4%BB%E6%80%A7%E4%BD%8D%E7%82%B9 维基百科Active_site#^ Alberts, B (2010). Essential Cell Biology. Garland Science. p. 91.#^ Campbell, P (2006). Biochemistry Illustrated. Elsevier. pp. 83–85.#^ Kool ET (1984). "Active site tightness and substrate fit in DNA replication". Annual Review of Biochemistry 71: 191–219. doi:10.1146/annurev.biochem.71.110601.135453.#^ a b Sullivan SM (2008). "Enzymes with lid-活性位点gated active sites must operate by an induced fit mechanism instead of conformational selection". Proceedings of the National Academy of Sciences of the United States of America 105: 13829–13834. doi:10.1073/pnas.0805364105.#^ a b Schechter I (2005). "Mapping of the active site of proteases in the 1960s and rational design of inhibitors/drugs in the 1990s". Current Protein and Peptide Science 6: 501–512. doi:10.2174/138920305774933286.#^ a b c DeDecker BS (2000). "Allosteric drugs: thinking outside the active-site box". Chemistry and Biology 7: 103–107. doi:10.1016/S1074-5521(00)00115-0.#^ Zuercher M (2008). "Structure-Based Drug Design: Exploring the Proper Filling of Apolar Pockets at Enzyme Active Sites". Journal of Organic Chemistry 73: 4345–4361. doi:10.1021/jo800527n.#^ Powers R (2006). "Comparison of protein active site structures for functional annotation of proteins and drug design". Proteins - Structure, Function and Bioinformatics 65: 124–135. doi:10.1002/prot.21092.    [[Category:酶]] [[Category:催化]]
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