α-酮戊二酸脱氢酶是[[原发性]][[胆汁性肝硬变]]中的[[自身抗原]]，这是一种急性[[肝脏]][[衰竭]]。由此所产生的[[抗体]]似乎专门识别那些由[[炎症]][[免疫反应]]所导致的被氧化的[[蛋白质]]。这类[[炎症反应]]中的一些可被解释为谷[[蛋白]][[过敏]]<ref name="pmid17657817"></ref>。其他的[[线粒体]]自身抗原包括了丙酮酸脱氢酶与支链α-酮酸脱氢酶复合体，这些自身抗原可被[[抗线粒体抗体]]所识别。在许多[[神经]]变性疾病期间，α-酮戊二酸脱氢酶复合体的活性会下降很多。
==参考文献==
<references />
# Bunik V, Westphal AH, de Kok A: ''Kinetic properties of the 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii evidence for the formation of a precatalytic complex with 2-oxoglutarate.'' Eur J Biochem 2000; 267(12): 3583-91. PMID 10848975.
# Bunik VI, Strumilo S: "Regulation of Catalysis Within Cellular Network: Metabolic and Signaling Implications of the 2-Oxoglutarate Oxidative Decarboxylation." Current Chemical Biology, 2009, 3: 279-290
# Bunik VI, Fernie AR: "Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation." Biochem. J. 2009, 422: 405–421
# L. Trofimova, M. Lovat, A. Groznaya, E. Efimova, T. Dunaeva, M. Maslova, A. Graf, and V. Bunik: "Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases." International Journal of Alzheimer Disease 2010; Volume 2010, Article ID 749061, 8 pages, doi:10.4061/2010/749061, http://www.sage-hindawi.com/journals/ijad/2010/749061.html
==外部链接==
*
[[Category:EC 1.2.4]]
[[Category:自身抗原]] [[Category:三羧酸循环]]
==参考来源==
*[http://zh.wikipedia.org/wiki/%E9%85%AE%E6%88%8A%E4%BA%8C%E9%85%B8%E8%84%B1%E6%B0%A2%E9%85%B6%E5%A4%8D%E5%90%88%E4%BD%93 维基百科-酮戊二酸脱氢酶复合体]
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