更改

在过去这些年中，许多实验室证明了这些[[膜蛋白]]除了可以做传统的离子运输外，亦可借由调控蛋白质上[[酪胺酸]]的[[磷酸化]]来结合细胞间的哇吧因(ouabain)传递讯息进入细胞内。借由哇吧因来触发蛋白质磷酸化产生的下游讯息包括[[有丝分裂]]活化[[蛋白质激酶]](mitogen-activated protein kinase, MAPK)讯息的梯瀑效应(cascade)的活化、[[粒线体]]活性氧（reactive oxygen species, ROS）的产生、C型[[磷脂酶]]（phospholipase C, PLC）及[[肌醇三磷酸]][[受体]]（inositol triphosphate receptor, IP₃R）的活化。[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15975899 Na/K-ATPase Tethers Phospholipase C and IP3 Receptor into a Calcium-regulatory Complex] by Zhaokan Yuan, Ting Cai, Jiang Tian, Alexander V. Ivanov, David R. Giovannucci, and Zijian Xie in Molecular Biology of the Cell (2005) volume 16, pages 4034-4045.<br /> 蛋白质[[交互作用]]对钠钾帮浦媒介的讯息传递是很重要的，如：钠钾帮浦与无接收子酪胺酸[[磷酸酶]]（Src，一种没有受体得酪胺酸[[激酶]]）结合形成接收子[[复合物]]（receptor complex）。[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16267270 Binding of Src to Na+/K+-ATPase Forms a Functional Signaling Complex] by Jiang Tian, Ting Cai, Zhaokan Yuan, Haojie Wang, Lijun Liu, Michael Haas, Elena Maksimova,‡ Xin-Yun Huang and Zi-Jian Xie in Molecular Biology of the Cell (2005) volume 17, pages 317-326.钠钾帮浦亦会与[[锚蛋白]]（ankyrin）、肌醇三磷酸受体（IP₃R）、肌醇三磷酸激酶（PI₃K）、C型磷脂酶γ（PLC-γ）及切丝[[蛋白]]（cofilin）结合。[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1221581 Interaction of the alpha subunit of Na,K-ATPase with cofilin] by K. Lee, J. Jung, M. Kim and G. Guidotti in [[Biochemical Journal|The Biochemical Journal]] (2001) volume 353, pages 377–385.