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创建页面，内容为“{{enzyme | Name = 乌头酸水合酶 | EC_number = 4.2.1.3 | CAS_number = 9024-25-3 | IUBMB_EC_number = 4/2/1/3 | GO_code = 0003994 | image = 7ACN.jpg | width = | c...”
{{enzyme
| Name = 乌头酸水合酶
| EC_number = 4.2.1.3
| CAS_number = 9024-25-3
| IUBMB_EC_number = 4/2/1/3
| GO_code = 0003994
| image = 7ACN.jpg
| width =
| caption = 结合铁-硫簇的猪顺乌头酸酶插画。按二级结构将蛋白质着色，铁原子以蓝色表示，硫原子以红色表示<ref name="pmid1547214">; </ref>。
}}
{{Infobox protein family
| Symbol = 顺乌头酸酶
| Name = 顺乌头酸酶家族<br />（乌头酸水合酶）
| image = PDB 1aco EBI.jpg
| width =
| caption = 顺乌头酸酶结构<ref name="pmid8151704">; </ref>。
| Pfam = PF00330
| InterPro = IPR001030
| SMART =
| PROSITE = PDOC00423
| SCOP = 1aco
| TCDB =
| OPM family =
| OPM protein =
}}
''''''顺乌头酸酶'''<ref>[http://www.term.gov.cn/pages/homepage/result2.jsp?id=332348&subid=10001798&subject=%E9%85%B6&subsys=%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6%E4%B8%8E%E5%88%86%E5%AD%90%E7%94%9F%E7%89%A9%E5%AD%A6]</ref>'''（，简称为'''[[乌头酸]]酶'''，）是一种在三[[羧酸]]循[[环中]][[催化]][[柠檬酸]]通过顺乌头酸中间步骤[[立体专一性]]可逆异构化为[[异柠檬酸]]的酶，这是一个非[[氧化还原]]步骤<ref name="pmid8262329"></ref><ref name="pmid11848829"></ref><ref name="pmid11848830"></ref>。
<gallery>
Image:Citrate wpmp.png|<center>柠檬酸</center>
Image:Cis-Aconitate wpmp.png|<center>乌头酸</center>
Image:Threo-Ds-isocitrate wpmp.png|<center>异柠檬酸</center>
</gallery>
== 家族成员 ==
从[[细菌]]到人类，顺乌头酸酶都可以被表达出来。人类表达以下两种[[同工酶]]：
{|
| {{protein
| Name = 顺乌头酸酶1，可溶性
| caption =
| image =
| width =
| HGNCid = 117
| Symbol = ACO1
| AltSymbols = IREB1
| EntrezGene = 48
| OMIM = 100880
| RefSeq = NM_002197
| UniProt = P21399
| PDB =
| ECnumber = 4.2.1.3
| Chromosome = 9
| Arm = p
| Band = 21.1
| LocusSupplementaryData =
}}
| {{protein
| Name = 顺乌头酸酶2，线粒体酶
| caption =
| image =
| width =
| HGNCid = 118
| Symbol = ACO2
| AltSymbols = ACONM
| EntrezGene = 50
| OMIM = 100850
| RefSeq = NM_001098
| UniProt = Q99798
| PDB =
| ECnumber = 4.2.1.3
| Chromosome = 22
| Arm = q
| Band = 13.2
| LocusSupplementaryData =
}}
|}
==参考文献==
== 深入阅读 ==
*
== 外部链接 ==
*
* - the Aconitase structure in interactive 3D
[[Category:EC 4.2.1]]
[[Category:铁-硫蛋白]] [[Category:兼职蛋白质]]
==参考来源==
*[http://zh.wikipedia.org/wiki/%E9%A1%BA%E4%B9%8C%E5%A4%B4%E9%85%B8%E9%85%B6 维基百科-顺乌头酸酶]
== 百科帮你涨知识 ==
[http://www.zk120.com/ji/ 查找更多中医古籍]
[http://www.zk120.com/an/ 查找更多名老中医的医案]
[http://www.zk120.com/fang/ 查找更多方剂]
| Name = 乌头酸水合酶
| EC_number = 4.2.1.3
| CAS_number = 9024-25-3
| IUBMB_EC_number = 4/2/1/3
| GO_code = 0003994
| image = 7ACN.jpg
| width =
| caption = 结合铁-硫簇的猪顺乌头酸酶插画。按二级结构将蛋白质着色，铁原子以蓝色表示，硫原子以红色表示<ref name="pmid1547214">; </ref>。
}}
{{Infobox protein family
| Symbol = 顺乌头酸酶
| Name = 顺乌头酸酶家族<br />（乌头酸水合酶）
| image = PDB 1aco EBI.jpg
| width =
| caption = 顺乌头酸酶结构<ref name="pmid8151704">; </ref>。
| Pfam = PF00330
| InterPro = IPR001030
| SMART =
| PROSITE = PDOC00423
| SCOP = 1aco
| TCDB =
| OPM family =
| OPM protein =
}}
''''''顺乌头酸酶'''<ref>[http://www.term.gov.cn/pages/homepage/result2.jsp?id=332348&subid=10001798&subject=%E9%85%B6&subsys=%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6%E4%B8%8E%E5%88%86%E5%AD%90%E7%94%9F%E7%89%A9%E5%AD%A6]</ref>'''（，简称为'''[[乌头酸]]酶'''，）是一种在三[[羧酸]]循[[环中]][[催化]][[柠檬酸]]通过顺乌头酸中间步骤[[立体专一性]]可逆异构化为[[异柠檬酸]]的酶，这是一个非[[氧化还原]]步骤<ref name="pmid8262329"></ref><ref name="pmid11848829"></ref><ref name="pmid11848830"></ref>。
<gallery>
Image:Citrate wpmp.png|<center>柠檬酸</center>
Image:Cis-Aconitate wpmp.png|<center>乌头酸</center>
Image:Threo-Ds-isocitrate wpmp.png|<center>异柠檬酸</center>
</gallery>
== 家族成员 ==
从[[细菌]]到人类，顺乌头酸酶都可以被表达出来。人类表达以下两种[[同工酶]]：
{|
| {{protein
| Name = 顺乌头酸酶1，可溶性
| caption =
| image =
| width =
| HGNCid = 117
| Symbol = ACO1
| AltSymbols = IREB1
| EntrezGene = 48
| OMIM = 100880
| RefSeq = NM_002197
| UniProt = P21399
| PDB =
| ECnumber = 4.2.1.3
| Chromosome = 9
| Arm = p
| Band = 21.1
| LocusSupplementaryData =
}}
| {{protein
| Name = 顺乌头酸酶2，线粒体酶
| caption =
| image =
| width =
| HGNCid = 118
| Symbol = ACO2
| AltSymbols = ACONM
| EntrezGene = 50
| OMIM = 100850
| RefSeq = NM_001098
| UniProt = Q99798
| PDB =
| ECnumber = 4.2.1.3
| Chromosome = 22
| Arm = q
| Band = 13.2
| LocusSupplementaryData =
}}
|}
==参考文献==
== 深入阅读 ==
*
== 外部链接 ==
*
* - the Aconitase structure in interactive 3D
[[Category:EC 4.2.1]]
[[Category:铁-硫蛋白]] [[Category:兼职蛋白质]]
==参考来源==
*[http://zh.wikipedia.org/wiki/%E9%A1%BA%E4%B9%8C%E5%A4%B4%E9%85%B8%E9%85%B6 维基百科-顺乌头酸酶]
== 百科帮你涨知识 ==
[http://www.zk120.com/ji/ 查找更多中医古籍]
[http://www.zk120.com/an/ 查找更多名老中医的医案]
[http://www.zk120.com/fang/ 查找更多方剂]
